Tobias L D, Hamilton J G
Lipids. 1979 Feb;14(2):181-93. doi: 10.1007/BF02533870.
The purpose of this presentation is to review the current state of knowledge regarding 5,8,11,14-eicosatetraynoic acid (ETYA, Ro 3-1428) and its effects on lipid metabolism. Accordingly, the topics discussed include hypocholesterolemic and dermatological studies involving ETYA in both animals and man, as well as the effects of ETYA on desaturase enzymes. Metabolic studies involving ETYA are also noted. Primary interest is focused on the effects of ETYA on selected processes of arachidonate metabolism, and the effect of ETYA on inflammation, platelet aggregation and tumor growth are discussed, keeping in mind the relevance of arachidonate metabolism to these processes.
本报告的目的是回顾关于5,8,11,14-二十碳四烯酸（ETYA，Ro 3-1428）及其对脂质代谢影响的当前知识状态。因此，讨论的主题包括涉及ETYA在动物和人类中的降胆固醇和皮肤病学研究，以及ETYA对去饱和酶的影响。还提到了涉及ETYA的代谢研究。主要关注点集中在ETYA对花生四烯酸代谢特定过程的影响，并讨论了ETYA对炎症、血小板聚集和肿瘤生长的影响，同时牢记花生四烯酸代谢与这些过程的相关性。
