La Vecchia C, Franceschi S, Decarli A, Gentile A, Liati P, Regallo M, Tognoni G
Int J Cancer. 1984 May 15;33(5):559-62. doi: 10.1002/ijc.2910330502.
The relation between ovarian cancer and coffee drinking habits was evaluated in a case-control study of 247 histologically confirmed epithelial ovarian cancers and 494 age-matched controls, admitted to hospital for acute conditions apparently unrelated to coffee consumption. Compared to rates for women who had never drunk coffee, the crude relative risk estimates for those who drank less than two, two or three, and four or more cups per day were 1.3, 1.5 and 1.4 respectively; however, when allowance was made for smoking habits, these risk estimates became 1.3, 1.7 and 1.8 respectively, and a significant linear trend of increasing risk with more elevated coffee consumption was evident. These results were not explained by various other potential confounding factors, including the major risk factors for ovarian cancer, but we had no information on dietary variables. The relative risk, however, did not increase with increasing duration of use. The findings of this study give apparent support in favour of the hypothesis that coffee consumption, or related dietary variables, may be associated with the risk of epithelial ovarian cancer. Further studies in different settings, however, are required in order to establish whether this association is real, and if so, whether it is causal.
在一项病例对照研究中，对247例经组织学确诊的上皮性卵巢癌患者和494例年龄匹配的对照者进行了评估，这些对照者因明显与咖啡摄入无关的急性病入院。与从未喝咖啡的女性相比，每天饮用少于两杯、两杯或三杯、四杯及以上咖啡的人群的粗相对风险估计值分别为1.3、1.5和1.4；然而，在考虑吸烟习惯后，这些风险估计值分别变为1.3、1.7和1.8，且随着咖啡摄入量增加，风险呈显著线性上升趋势。这些结果无法用包括卵巢癌主要危险因素在内的其他各种潜在混杂因素来解释，但我们没有饮食变量方面的信息。然而，相对风险并未随着使用时间的增加而上升。本研究结果显然支持这样一种假设，即咖啡消费或相关饮食变量可能与上皮性卵巢癌风险相关。然而，需要在不同环境下进行进一步研究，以确定这种关联是否真实存在，以及如果存在，是否具有因果关系。
