Fitzpatrick P J, Thompson G A, Easterbrook W M, Gallie B L, Payne D G
Int J Radiat Oncol Biol Phys. 1984 Apr;10(4):449-54. doi: 10.1016/0360-3016(84)90023-3.
We report 1,166 tumors of the eyelids that were treated by single or fractionated exposures to doses of 20-60 Gy. The five year tumor control rate was 95% for basal cell and 93.3% for squamous cell carcinoma. Irradiation was equally successful in primary cases and in those recurrent following surgery. Recurrence following irradiation was managed by surgery or further irradiation. The cosmetic and functional results were generally excellent and readily accepted by most patients. The overall complication rate was 9.6% with fewer than one-half rated as serious; these problems mainly occurred with large tumors that had destroyed normal tissues. In only 14 (1.2%) patients was death related to the tumor. Approximately one-half of the patients received a dose of 35 Gy in five daily fractions, one-quarter, 20 to 22.5 Gy in a single exposure and the others with larger tumors 42.5-60 Gy in 10 to 30 exposures in two to six weeks. Radiotherapy is a safe and cost effective treatment for eyelid tumors.
我们报告了1166例眼睑肿瘤患者，这些患者接受了单次或分次照射，剂量为20 - 60 Gy。基底细胞癌的五年肿瘤控制率为95%，鳞状细胞癌为93.3%。放疗在原发性病例和手术后复发的病例中同样成功。放疗后复发的病例通过手术或进一步放疗进行处理。美容和功能效果总体良好，大多数患者易于接受。总体并发症发生率为9.6%，其中严重并发症不到一半；这些问题主要发生在破坏正常组织的大肿瘤患者中。只有14例（1.2%）患者的死亡与肿瘤相关。大约一半的患者在五天内分五次接受35 Gy的剂量，四分之一的患者单次接受20至22.5 Gy的剂量，其他肿瘤较大的患者在两到六周内分10至30次接受42.5 - 60 Gy的剂量。放射治疗是一种治疗眼睑肿瘤安全且具有成本效益的方法。
