Landolt A M, Osterwalder V
J Clin Endocrinol Metab. 1984 Jun;58(6):1179-83. doi: 10.1210/jcem-58-6-1179.
Prolonged treatment of patients with pituitary prolactinomas with bromocriptine may increase the consistency of the tumor thereby making selective extirpation more difficult. We made quantitative determinations of the amount of perivascular fibrous tissue in prolactinomas on random electron micrographs, comparing a group of 21 patients treated with bromocriptine for periods longer than 3 months and a control group of 21 patients who did not receive bromocriptine. Statistical analysis of the data showed a significant increase of perivascular fibrous tissue in the treated group (P less than 0.002). We suspect that this fibrosis is a consequence of the rapid shrinkage of prolactinoma cells caused by bromocriptine. Presumably, this cell shrinkage causes enlargement of the extracellular and perivascular spaces which are filled by the deposition of collagen, producing a more dense consistency of the adenoma.
用溴隐亭对垂体泌乳素瘤患者进行长期治疗可能会增加肿瘤的质地，从而使选择性切除更加困难。我们在随机电子显微镜照片上对泌乳素瘤中血管周围纤维组织的量进行了定量测定，比较了一组接受溴隐亭治疗超过3个月的21例患者和一组未接受溴隐亭治疗的21例对照患者。数据的统计分析显示，治疗组中血管周围纤维组织显著增加（P小于0.002）。我们怀疑这种纤维化是溴隐亭导致泌乳素瘤细胞快速萎缩的结果。据推测，这种细胞萎缩导致细胞外和血管周围间隙扩大，这些间隙被胶原蛋白沉积填充，使腺瘤质地更致密。
