Dietz A J, Carlson J D, Khalil S K, Nygard G
J Clin Pharmacol. 1984 Apr;24(4):205-8. doi: 10.1002/j.1552-4604.1984.tb01832.x.
As a nonspecific measure of increased metabolic clearance, the kinetics of acetaminophen was studied in a group of nondrinking controls and alcoholics who had ceased drinking within the previous 48 hours. After a single 1-Gm dose of acetaminophen, blood levels showed a significant increase in nondrinking controls over the alcoholics. The area under the curve for the alcoholics was smaller than that for the controls. Further studies are indicated to determine the quantities of the various metabolites of acetaminophen in both groups.
作为代谢清除增加的一种非特异性测量方法，对一组不饮酒的对照者和在过去48小时内已戒酒的酗酒者进行了对乙酰氨基酚的动力学研究。给予1克单次剂量的对乙酰氨基酚后，不饮酒对照者的血药浓度相较于酗酒者显著升高。酗酒者的曲线下面积小于对照者。需要进一步研究以确定两组中对乙酰氨基酚各种代谢物的量。
