Costa A, De Filippis V, Barbeni M, Bestagno M, Giraudi G, Grillo C
J Endocrinol Invest. 1984 Apr;7(2):103-10. doi: 10.1007/BF03348398.
Urinary iodine (I) and serum and urinary thiocyanates (SCN-) were determined in sample groups from 12 areas of endemic goiter in Italy. The mean urinary I level of 637 subjects with thyroid 0 was 67 +/- 31 (mean +/- SD) microgram/liter, that of 648 with goiter 54 +/- 29 micrograms/liter. Mean serum and urinary SCN- were 2.44 +/- 1.36 mg/liter and 2.58 +/- 1.36 mg/liter in 887 and 1531 subjects, respectively. The thiocyanates data enabled a distinction to be drawn between two groups (populations). Population I included 73% of the adults and 92% of the school-children (6-16 yr). Its thiocyanate values were logarithmically spread around means of 1.24 +/- 0.6 mg/liter (serum) and 1.24 +/- 0.57 mg/liter (urine), whereas those of population II were widely dispersed around means of 6.1 +/- 3.0 mg/liter and 8.08 +/- 5.5 mg/liter respectively. The boundary between the two populations was set at 3 mg/liter urine SCN-. This distinction was substantiated by the fact that 90% of those in population II smoked 10 or more cigarettes a day, whereas population I comprised occasionally smokers only. It is believed that only the values in population I can be regarded as representative of thiocyanates either endogenous or due to dietary dietary intake: these values never differed more than 60% regardless of the areas, seasons, or dietary habits. As urinary SCN- levels rose, there was also an increase in urinary iodine excretion within certain limits. This, however, did not interfere with thyroid secretion. The urinary I/SCN- ratio was lower in subjects with goiter. This was because their iodine levels were lower, whereas SCN- values were much the same in subjects with and without goiter. We have found no correlation between thiocyanate itself and goiter.
对来自意大利12个地方性甲状腺肿地区的样本组测定了尿碘（I）以及血清和尿中的硫氰酸盐（SCN-）。637名甲状腺正常受试者的平均尿碘水平为67±31（均值±标准差）微克/升，648名甲状腺肿患者的平均尿碘水平为54±29微克/升。887名和1531名受试者的血清和尿中硫氰酸盐的平均水平分别为2.44±1.36毫克/升和2.58±1.36毫克/升。硫氰酸盐数据使得能够区分两组人群。第一组人群包括73%的成年人和92%的学龄儿童（6至16岁）。其硫氰酸盐值以对数形式分布在血清均值1.24±0.6毫克/升和尿均值1.24±0.57毫克/升周围，而第二组人群的硫氰酸盐值则分别广泛分布在均值6.1±3.0毫克/升和8.08±5.5毫克/升周围。两组人群的界限设定为尿硫氰酸盐3毫克/升。这种区分得到了以下事实的证实：第二组人群中90%的人每天吸烟10支或更多，而第一组人群仅包括偶尔吸烟者。据信，只有第一组人群的值可被视为内源性或饮食摄入所致硫氰酸盐的代表：无论地区、季节或饮食习惯如何，这些值的差异从未超过60%。随着尿硫氰酸盐水平升高，在一定限度内尿碘排泄也会增加。然而，这并未干扰甲状腺分泌。甲状腺肿患者的尿碘/硫氰酸盐比值较低。这是因为他们的碘水平较低，而甲状腺肿患者和非甲状腺肿患者的硫氰酸盐值大致相同。我们未发现硫氰酸盐本身与甲状腺肿之间存在相关性。
