Andriulli A, Masoero G, Benitti V, Amato A, Piantino P, Gaia E
J Clin Gastroenterol. 1984 Jun;6(3):239-44.
To assess the relation between circulating cathodic trypsinogen (CT) levels and exocrine pancreatic function, and to compare the radioimmunological with the enzymatic measurement of duodenal trypsin, we evaluated exocrine pancreatic function in 34 controls and in 32 patients with proven chronic pancreatitis (CP). There was no relation between CT and the volume rate of pancreatic secretion, nor did serum CT levels correlate with the concentration output of duodenal bicarbonate in controls. However, in CP patients, there was a low value of the correlation coefficient. A good relationship between serum CT levels and duodenal trypsin secretion was detected when the trypsin content was expressed as the mean value of both concentration and output. The enzymatic estimation of duodenal trypsin was related closely to its radioimmunological measurement, but there was better correlation of serum CT to duodenal immunoreactive than to enzymatic trypsin. In patients with CP, low levels were observed in 29% of cases with serum CT estimation, in 75% with duodenal bicarbonate, and in 63% and 79% with enzymatic and immunoreactive trypsin outputs, respectively. We conclude that serum CT levels may reflect the functioning mass of pancreatic acinar cells and that in assessing pancreatic secretory capacity, the immunoreactive measurement of trypsin excretion is more sensitive than the enzymatic measurement and as accurate as bicarbonate output.
为评估循环中胰蛋白酶原（CT）水平与胰腺外分泌功能之间的关系，并比较十二指肠胰蛋白酶的放射免疫测定法与酶法测定，我们对34名对照者和32名经证实的慢性胰腺炎（CP）患者的胰腺外分泌功能进行了评估。CT与胰腺分泌的容积率之间无相关性，在对照者中血清CT水平也与十二指肠碳酸氢盐的浓度输出无关。然而，在CP患者中，相关系数值较低。当将胰蛋白酶含量表示为浓度和输出的平均值时，血清CT水平与十二指肠胰蛋白酶分泌之间存在良好的关系。十二指肠胰蛋白酶的酶法测定与其放射免疫测定密切相关，但血清CT与十二指肠免疫反应性胰蛋白酶的相关性优于与酶法测定的胰蛋白酶的相关性。在CP患者中，血清CT测定有29%的病例水平较低，十二指肠碳酸氢盐测定有75%的病例水平较低，酶法测定和免疫反应性胰蛋白酶输出分别有63%和79%的病例水平较低。我们得出结论，血清CT水平可能反映胰腺腺泡细胞的功能质量，并且在评估胰腺分泌能力时，胰蛋白酶排泄的免疫反应性测定比酶法测定更敏感，且与碳酸氢盐输出一样准确。
