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异丙醇与异丙醇致死案例——十年经验

Isopropanol and isopropanol deaths-ten years' experience.

作者信息

Alexander C B, McBay A J, Hudson R P

出版信息

J Forensic Sci. 1982 Jul;27(3):541-8.

PMID:7119710
Abstract

A population of persons who were found, at death, to have significant levels of isopropyl alcohol (isopropanol) in their blood is described. The role of isopropanol in causing death is reviewed in 57 fatal cases. The contribution of acetone, the major metabolite of isopropanol, to death is assessed. Results indicate that mixed alcohol poisoning with ethanol and isopropanol suggests decreased production of acetone. Modalities for antemortem and postmortem detection of isopropanol are presented.

摘要

本文描述了一群在死亡时被发现血液中异丙醇(异丙基酒精)含量显著的人。回顾了57例致命病例中异丙醇在导致死亡方面的作用。评估了异丙醇的主要代谢产物丙酮对死亡的影响。结果表明,乙醇和异丙醇混合酒精中毒表明丙酮生成减少。介绍了异丙醇生前和死后检测的方法。

相似文献

1
Isopropanol and isopropanol deaths-ten years' experience.异丙醇与异丙醇致死案例——十年经验
J Forensic Sci. 1982 Jul;27(3):541-8.
2
Serum determinations in toxic isopropanol ingestion.
Am J Emerg Med. 1992 May;10(3):200-2. doi: 10.1016/0735-6757(92)90208-F.
3
[Acute oral poisoning with isopropyl alcohol in alcoholics].[酒精中毒患者的异丙醇急性口服中毒]
Przegl Lek. 1997;54(6):459-63.
4
[Acetone and isopropanol concentration of blood in relation to acute and chronic alcoholism].
Blutalkohol. 1988 Mar;25(2):80-96.
5
The use of delta osmolality to predict serum isopropanol and acetone concentrations.利用渗透压差预测血清异丙醇和丙酮浓度。
Pharmacotherapy. 1993 Jan-Feb;13(1):60-3.
6
Comparison of blood-ethanol concentration in deaths attributed to acute alcohol poisoning and chronic alcoholism.急性酒精中毒和慢性酒精中毒所致死亡的血液乙醇浓度比较。
J Forensic Sci. 2003 Jul;48(4):874-9.
7
Metabolism of acetone to isopropyl alcohol in rats and humans.大鼠和人类体内丙酮向异丙醇的代谢
J Forensic Sci. 1984 Apr;29(2):541-9.
8
Isopropanol ingestion: a report of six episodes with isopropanol and acetone serum concentration time data.
J Toxicol Clin Toxicol. 1991;29(1):11-21. doi: 10.3109/15563659109038593.
9
[Evaluation of an increased blood level of GGT, CDT, methanol, acetone and isopropanol in alcohol intoxicated automobile drivers. Alcoholism indicators instead of medical-psychological examination].[对酒精中毒汽车驾驶员血液中γ-谷氨酰转移酶、平均红细胞体积分布宽度、甲醇、丙酮和异丙醇水平升高的评估。用酒精中毒指标替代医学-心理检查]
Blutalkohol. 1994 Sep;31(5):273-314.
10
Toxic volatiles in alcoholic coma. A report of simultaneous determination of blood methanol, ethanol, isopropanol, acetaldehyde and acetone by gas chromatography.酒精性昏迷中的有毒挥发性物质。气相色谱法同时测定血液中甲醇、乙醇、异丙醇、乙醛和丙酮的报告。
Bull Los Angeles Neurol Soc. 1968 Jul;33(3):140-4.

引用本文的文献

1
Elevated blood-ethanol concentration promotes reduction of aliphatic ketones (acetone and ethyl methyl ketone) to secondary alcohols along with slower oxidation to aliphatic diols.血液乙醇浓度升高会促进脂肪族酮(丙酮和甲乙酮)还原为仲醇,同时减缓氧化为脂肪族二醇。
Arch Toxicol. 2024 Dec;98(12):4013-4019. doi: 10.1007/s00204-024-03860-w. Epub 2024 Sep 3.
2
A case of atypical neurological symptoms and high cerebro-spinal fluid acetone level due to transdermal exposure to isopropanol.一例因经皮接触异丙醇导致非典型神经症状和脑脊液丙酮水平升高的病例。
World J Emerg Med. 2023;14(2):152-154. doi: 10.5847/wjem.j.1920-8642.2023.015.
3
Putatively lethal ingestion of isopropyl alcohol-related case: interpretation of post mortem isopropyl alcohol and acetone concentrations remains challenging.
疑似致命性摄入异丙醇相关案例:死后异丙醇和丙酮浓度的解读仍然具有挑战性。
Int J Legal Med. 2021 Jan;135(1):175-182. doi: 10.1007/s00414-020-02444-4. Epub 2020 Oct 22.
4
Toxic alcohol diagnosis and management: an emergency medicine review.毒醇类中毒的诊断与治疗:急诊医学综述。
Intern Emerg Med. 2018 Apr;13(3):375-383. doi: 10.1007/s11739-018-1799-9. Epub 2018 Feb 9.