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降钙素对人体生长激素和胰岛素分泌的抑制作用。

Inhibitory effect of calcitonin on growth hormone and insulin secretion in man.

作者信息

Cantalamessa L, Catania A, Reschini E, Peracchi M

出版信息

Metabolism. 1978 Aug;27(8):987-92. doi: 10.1016/0026-0495(78)90143-9.

DOI:10.1016/0026-0495(78)90143-9
PMID:672618
Abstract

The effect of calcitonin administration on basal and arginine-stimulated growth hormone and insulin plasma levels was investigated. The intramuscular injection of synthetic salmon calcitonin (100 U MRC) in five normal subjects produced a significant decrease (p less than 0.05) in insulin concentration. The same amount of calcitonin given 15 min before an arginine infusion test in seven normal subjects significantly reduced the response of growth hormone (p less than 0.025) and insulin (p less than 0.005) to the stimulus.

摘要

研究了降钙素给药对基础及精氨酸刺激后的生长激素和胰岛素血浆水平的影响。对五名正常受试者肌肉注射合成鲑鱼降钙素(100 U MRC)后,胰岛素浓度显著降低(p < 0.05)。在七名正常受试者进行精氨酸输注试验前15分钟给予相同剂量的降钙素,显著降低了生长激素(p < 0.025)和胰岛素(p < 0.005)对该刺激的反应。

相似文献

1
Inhibitory effect of calcitonin on growth hormone and insulin secretion in man.降钙素对人体生长激素和胰岛素分泌的抑制作用。
Metabolism. 1978 Aug;27(8):987-92. doi: 10.1016/0026-0495(78)90143-9.
2
Effect of human calcitonin (hCT) on glucose- and arginine-stimulated insulin secretion.人降钙素(hCT)对葡萄糖和精氨酸刺激的胰岛素分泌的影响。
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引用本文的文献

1
Long- and short-term side effects and safety of calcitonin in man: a prospective study.降钙素对人体的长期和短期副作用及安全性:一项前瞻性研究。
Calcif Tissue Int. 1993 Feb;52(2):90-3. doi: 10.1007/BF00308314.
2
Calcitonin, as SMS 201-995, ameliorates the VIPoma syndrome.降钙素,如SMS 201-995,可改善血管活性肠肽瘤综合征。
J Endocrinol Invest. 1993 Jan;16(1):57-9. doi: 10.1007/BF03345831.
3
Effect of Calcitonin on plasma glucose, C-peptide, glucagon and growth hormone responses to arginine in insulin-dependent diabetic subjects.
降钙素对胰岛素依赖型糖尿病患者血浆葡萄糖、C肽、胰高血糖素及生长激素对精氨酸反应的影响。
Acta Diabetol Lat. 1981 Jul-Sep;18(3):235-41. doi: 10.1007/BF02047895.
4
Effects of calcium and calcitonin on circulating levels of glucagon and glucose in diabetes mellitus.钙和降钙素对糖尿病患者胰高血糖素和血糖循环水平的影响。
Diabetologia. 1981 May;20(5):547-52. doi: 10.1007/BF00252763.
5
Effects of synthetic salmon calcitonin administration on gastrin, immunoreactive insulin and growth hormone release after protein meal in uremic patients.
J Endocrinol Invest. 1981 Apr-Jun;4(2):185-8. doi: 10.1007/BF03350449.
6
Pharmacology and therapeutic use of calcitonin.降钙素的药理学与治疗用途。
Drugs. 1981 Apr;21(4):257-72. doi: 10.2165/00003495-198121040-00002.
7
Parathyroid hormone and calcitonin in glucose regulation.甲状旁腺激素与降钙素在葡萄糖调节中的作用
Eur J Pediatr. 1980 Dec;135(2):195-8. doi: 10.1007/BF00441641.
8
Does calcitonin modulate anterior pituitary hormone secretion?
J Endocrinol Invest. 1982 Sep-Oct;5(5):327-30. doi: 10.1007/BF03350522.
9
Parathyrin and calcitonin stimulate cyclic AMP accumulation in cultured murine brain cells.甲状旁腺素和降钙素刺激培养的鼠脑细胞中环状AMP的积累。
EMBO J. 1982;1(3):297-302. doi: 10.1002/j.1460-2075.1982.tb01163.x.
10
Calcitonin and insulin secretion in normal man: study with somatostatin and calcium.正常人体内降钙素与胰岛素的分泌:使用生长抑素和钙的研究
Acta Diabetol Lat. 1983 Jan-Mar;20(1):41-6. doi: 10.1007/BF02629128.