Sgambato S, Passariello N, Giugliano D, Torella R, D'Onofrio F
Acta Diabetol Lat. 1981 Jul-Sep;18(3):235-41. doi: 10.1007/BF02047895.
The present study was aimed at investigating the effect of calcitonin on plasma glucose, C-peptide, glucagon and growth hormone (GH) responses to arginine in insulin-dependent diabetic subjects. For this purpose, 6 insulin-requiring diabetics were submitted to an arginine tolerance test twice, in basal conditions and during the simultaneous infusion of salmon calcitonin (100 MRC) plus arginine in random order. Calcitonin caused a clear inhibition of the plasma glucose rise triggered by the amino acid, without significant modifications of the plasma C-peptide and glucagon responses. A significant rebound of plasma glucose was seen after calcitonin was stopped. Plasma GH rise following arginine administration was significantly inhibited by calcitonin. These findings suggest some positive interferences of calcitonin with the arginine-induced plasma glucose increase in insulin-dependent diabetes.
本研究旨在探讨降钙素对胰岛素依赖型糖尿病患者血浆葡萄糖、C肽、胰高血糖素以及生长激素（GH）对精氨酸反应的影响。为此，6名需要胰岛素治疗的糖尿病患者在基础状态下以及同时随机输注鲑鱼降钙素（100 MRC）加精氨酸的过程中，接受了两次精氨酸耐量试验。降钙素可明显抑制由氨基酸引发的血浆葡萄糖升高，而血浆C肽和胰高血糖素反应无显著改变。停用降钙素后可见血浆葡萄糖显著反弹。降钙素显著抑制了精氨酸给药后血浆GH的升高。这些发现提示降钙素对胰岛素依赖型糖尿病中精氨酸诱导的血浆葡萄糖升高存在一些积极的干扰作用。
