Laas R
J Neurol Neurosurg Psychiatry. 1984 Apr;47(4):365-71. doi: 10.1136/jnnp.47.4.365.
In 106 slightly anaesthetised adult mongolian gerbils one common carotid artery (CCA) was ligated and the blood pressure in the distal and in the proximal stump was monitored for 8 minutes. The mean distal CCA stump pressure of the 39 nonsurvivors was 15 (+/- 6) mm Hg, that of the 25 survivors with retinocerebral infarcts was 25 (+/- 6) mm Hg, and that of the 42 intact survivors was 31 (+/- 7) mm Hg. The corresponding mean arterial blood pressures (MABP), as measured in the proximal CCA stump, were 81 (+/- 12) mm Hg, 84 (+/- 13) mm Hg, and 87 (+/- 11) mm Hg, respectively. There were no differences between the samples concerning sex, body weight, rectal temperature, arterial blood gases, arterial pH, and haematocrit. Measurements in a second series of 10 awake gerbils showed that the mean values of MABP, heart rate, and respiratory rate of the nonsurvivors were less than those of the survivors during 90 minutes after CCA ligation. It is inferred that in the mongolian gerbil the lower threshold of the arterial blood pressure for the development of brain infarcts ranges within 22 and 25 mm Hg, that is, within the values found in monkeys and cats. The longlasting depression of respiration and circulation in the nonsurvivors is considered to be related to the phenomenon of diaschisis .
在106只轻度麻醉的成年蒙古沙鼠中，结扎一条颈总动脉（CCA），并监测远端和近端残端血压8分钟。39只未存活者的颈总动脉远端残端平均血压为15（±6）mmHg，25只发生视网膜脑梗死的存活者为25（±6）mmHg，42只完整存活者为31（±7）mmHg。在颈总动脉近端残端测量的相应平均动脉血压（MABP）分别为81（±12）mmHg、84（±13）mmHg和87（±11）mmHg。样本在性别、体重、直肠温度、动脉血气、动脉pH值和血细胞比容方面无差异。在另一组10只清醒沙鼠中的测量结果显示，在结扎颈总动脉后90分钟内，未存活者的平均动脉血压、心率和呼吸频率平均值低于存活者。据推断,在蒙古沙鼠中,发生脑梗死的动脉血压下限在22至25mmHg之间,即与在猴子和猫中发现的值范围相同。未存活者呼吸和循环的长期抑制被认为与交叉性小脑神经机能联系失联络现象有关。
