Peters A M, Walport M J, Bell R N, Lavender J P
J Nucl Med. 1984 Jan;25(1):86-90.
Following bolus intravenous injection of In-111-labeled autologous platelets in humans, splenic blood flow (SBF) was measured by compartmental analysis of the equilibration of platelets between blood and the intrasplenic platelet pool. The result correlated closely (r = 0.94, p less than 0.001) with SBF measured from analysis of the first-pass time-activity curve recorded over the spleen by external detection. The intrasplenic platelet transit time (tp), measured concurrently with SBF from compartmental analysis, correlated closely (r = 0.78, p less than 0.001) with tp measured from deconvolution analysis. These correlations appear to support the use of compartmental analysis of the equilibration of radiolabeled platelets between blood and the intrasplenic platelet pool as a valid technique for the simultaneous measurement of SBF and tp. Both of these parameters have potential clinical usefulness for the understanding of intrasplenic platelet kinetics in a variety of disorders.
在人体静脉注射In-111标记的自体血小板后，通过对血液与脾内血小板池之间血小板平衡的房室分析来测量脾血流量（SBF）。该结果与通过外部检测记录的脾脏首过时间-活性曲线分析所测得的SBF密切相关（r = 0.94，p < 0.001）。与SBF同时通过房室分析测得的脾内血小板转运时间（tp），与通过去卷积分析测得的tp密切相关（r = 0.78，p < 0.001）。这些相关性似乎支持将放射性标记血小板在血液与脾内血小板池之间平衡的房室分析作为同时测量SBF和tp的有效技术。这两个参数对于理解各种疾病中的脾内血小板动力学均具有潜在的临床应用价值。
