Peters A M, Lavender J P
Eur J Clin Invest. 1982 Jun;12(3):191-5. doi: 10.1111/j.1365-2362.1982.tb00992.x.
The kinetics of 111In platelets have been investigated in human subjects using a gamma camera and computer system. Time activity curves were recorded over the spleen, chest and liver, following intravenous bolus injection of autologous radio-labelled platelets. Splenic blood flow expressed as the percentage of total blood volume entering the spleen in unit time, and intrasplenic platelet transit time were calculated from the time activity curves. Spleen size was recorded from the camera images. Splenic blood flow increased with increasing spleen size (r = 0.56, P less than 0.001). Platelet transit time showed an inverse relationship with a semi-quantitative estimate of splenic perfusion (i.e. splenic blood flow per unit volume spleen; r = 0.64, P less than 0.001) but was not related to spleen size. At high rates of estimated splenic perfusion transit time appeared to reach a minimum value of about 7 min, whereas at low rates of estimated perfusion, transit time rose sharply to reach levels greater than 20 min. The effect of polycythaemia, taken to indicate high intrasplenic haematocrit on platelet transit time, was also investigated. Patients with secondary polycythaemia had elevated transit times (19 min SEM 1.6, n = 10) compared with primary polycythaemia (9.7 min SEM 0.8, n = 5) and normals (9.6 min SEM 0.5, n = 5). It was concluded that splenic perfusion was important in determining the duration of platelet transit.
已使用γ相机和计算机系统在人体受试者中研究了铟-111标记血小板的动力学。静脉推注自体放射性标记血小板后，记录脾脏、胸部和肝脏的时间-活性曲线。根据时间-活性曲线计算单位时间内进入脾脏的血流量占总血容量的百分比表示的脾血流量以及脾内血小板通过时间。从相机图像记录脾脏大小。脾血流量随脾脏大小增加而增加（r = 0.56，P < 0.001）。血小板通过时间与脾灌注的半定量估计值呈反比关系（即单位体积脾脏的脾血流量；r = 0.64，P < 0.001），但与脾脏大小无关。在估计的高脾灌注率下，通过时间似乎达到约7分钟的最小值，而在估计的低灌注率下，通过时间急剧上升至超过20分钟的水平。还研究了红细胞增多症（被认为表示脾内高血细胞比容）对血小板通过时间的影响。继发性红细胞增多症患者的通过时间升高（19分钟±标准误1.6，n = 10），而原发性红细胞增多症患者（9.7分钟±标准误0.8，n = 5）和正常人（9.6分钟±标准误0.5，n = 5）的通过时间较低。得出的结论是，脾灌注在决定血小板通过的持续时间方面很重要。
