Wadenvik H, Denfors I, Kutti J
Department of Medicine, Ostra Hospital, University of Göteborg, Sweden.
Br J Haematol. 1987 Oct;67(2):181-5. doi: 10.1111/j.1365-2141.1987.tb02324.x.
The relationship between the splenic blood flow and the intrasplenic platelet kinetics on the one hand, i.e. the two factors which govern the size of the exchangeable splenic platelet pool, and the spleen size on the other were assessed in 21 patients afflicted with haematologic disorders and variable splenomegaly. The splenic blood flow and intrasplenic platelet kinetics were measured using 111In-labelled platelets and compartmental analysis of their equilibration between circulating blood and splenic pool; the spleen size was determined by scintigraphy using 99mTc-labelled stannous colloid. Significant correlations were recorded between the spleen size and the splenic platelet pool size (r = 0.76; P less than 0.001) and between the spleen size and the splenic blood flow (r = 0.56; P less than 0.01). Splenic perfusion decreased significantly with increasing spleen size, but there was no relationship between the spleen size and the intrasplenic platelet transit time. However, an association was present between splenic perfusion and intrasplenic platelet transit time (r = -0.44; P less than 0.05). It is concluded that the splenic blood flow is the major determinant of the size of the exchangeable splenic platelet pool in splenomegalic states, and that the determination of spleen size using 99mTc-scintigraphy gives a rough estimation of the pool size. Splenic perfusion appears to be one of the factors which determine the intrasplenic platelet transit time.
对21例患有血液系统疾病且脾肿大程度各异的患者，评估了一方面脾血流量与脾内血小板动力学（即决定可交换脾血小板池大小的两个因素）之间的关系，以及另一方面脾大小与它们之间的关系。使用111In标记的血小板及其在循环血液和脾池之间平衡的房室分析来测量脾血流量和脾内血小板动力学；使用99mTc标记的锡胶体通过闪烁显像法测定脾大小。记录到脾大小与脾血小板池大小之间存在显著相关性（r = 0.76；P小于0.001），以及脾大小与脾血流量之间存在显著相关性（r = 0.56；P小于0.01）。随着脾大小增加，脾灌注显著降低，但脾大小与脾内血小板 transit 时间之间无关系。然而，脾灌注与脾内血小板 transit 时间之间存在关联（r = -0.44；P小于0.05）。得出结论：在脾肿大状态下，脾血流量是可交换脾血小板池大小的主要决定因素，并且使用99mTc闪烁显像法测定脾大小可对池大小进行粗略估计。脾灌注似乎是决定脾内血小板 transit 时间的因素之一。
