Schuster K, Bailey L B, Mahan C S
J Nutr. 1984 May;114(5):977-88. doi: 10.1093/jn/114.5.977.
The effect of maternal pyridoxine X HCl (PN-HCl) supplementation on the vitamin B-6 status of pregnant women and their infants at birth and on pregnancy outcome was investigated. Volunteer subjects were randomly assigned a daily vitamin B-6 supplement containing 0, 2.6, 5, 7.5, 10, 15 or 20 mg of PN-HCl in a double-blind study. The mean dietary vitamin B-6 intake of the group was 1.43 +/- 1.28 mg/day as estimated from 24-hour dietary recalls. Maternal plasma pyridoxal 5'-phosphate (PLP) levels were positively correlated with vitamin B-6 supplementation at 30 weeks gestation (r = 0.55, P less than 0.0005) and at delivery (r = 0.54, P less than 0.01). Cord plasma PLP levels reached a maximum when maternal PN-HCl supplementation was 7.5 mg and greater. Supplemental PN-HCl at the 7.5-mg level was required to prevent a decrease in maternal plasma PLP at delivery. Apgar scores at 1 minute after birth were higher (P less than 0.05) for infants whose mothers took 7.5 mg or more supplemental PN-HCl than for infants of mothers who took 5 mg or less. These findings indicate that a vitamin B-6 intake between 5.5 and 7.6 mg/day (diet plus supplement as pyridoxine equivalents) was required to maintain maternal plasma PLP levels at term at a level comparable to initial values.
研究了孕期补充盐酸吡哆醇（PN-HCl）对孕妇及其出生时婴儿的维生素B-6状况以及妊娠结局的影响。在一项双盲研究中，将志愿者随机分配，使其每日补充含0、2.6、5、7.5、10、15或20毫克PN-HCl的维生素B-6。根据24小时饮食回顾估计，该组的平均膳食维生素B-6摄入量为1.43±1.28毫克/天。孕30周时（r = 0.55，P<0.0005）和分娩时（r = 0.54，P<0.01），母体血浆磷酸吡哆醛（PLP）水平与维生素B-6补充量呈正相关。当母体PN-HCl补充量为7.5毫克及以上时，脐血血浆PLP水平达到最高。需要补充7.5毫克水平的PN-HCl以防止分娩时母体血浆PLP水平下降。母亲补充7.5毫克或更多PN-HCl的婴儿出生后1分钟的阿氏评分高于母亲补充5毫克或更少的婴儿（P<0.05）。这些发现表明，每天需要摄入5.5至7.6毫克的维生素B-6（膳食加补充剂，以吡哆醇当量计），才能在足月时将母体血浆PLP水平维持在与初始值相当的水平。
