Kang-Yoon S A, Kirksey A, Giacoia G, West K
Department of Foods and Nutrition, Purdue University, West Lafayette, IN.
Am J Clin Nutr. 1992 Sep;56(3):548-58. doi: 10.1093/ajcn/56.3.548.
Vitamin B-6 concentrations in human milk are known to respond rapidly to changes in maternal vitamin B-6 intake. In this study, mothers were supplemented during the first 28 d of lactation with 2 or 27 mg pyridoxine (PN)-HCl/d and a subgroup of breast-fed infants of the 2-mg/d-supplemented mothers were supplemented with 0.4 mg PN-HCl/d. Vitamin B-6 intakes of breast-fed infants reflected the amount of their mother's supplement; intakes were highest for the vitamin-supplemented infants. Vitamin B-6 intake of mothers was a strong indicator of infant vitamin B-6 status. Vitamin intake of infants correlated significantly with five measures of vitamin B-6 status. Plasma pyridoxal-5'-phosphate (PLP) concentrations and birth weight were the strongest predictors of infant growth that were examined. Alkaline phosphatase activity in the mother's milk and infant plasma reflected pyridoxal-PLP ratios in these fluids, suggesting that the enzyme acts in regulating circulating vitamer concentrations.
已知母乳中维生素B-6的浓度会对母体维生素B-6摄入量的变化迅速做出反应。在本研究中，母亲在哺乳期的前28天每天补充2毫克或27毫克盐酸吡哆醇（PN），并且补充2毫克/天的母亲所喂养的婴儿亚组每天额外补充0.4毫克盐酸PN。母乳喂养婴儿的维生素B-6摄入量反映了其母亲的补充量；维生素补充组婴儿的摄入量最高。母亲的维生素B-6摄入量是婴儿维生素B-6状态的有力指标。婴儿的维生素摄入量与维生素B-6状态的五项指标显著相关。血浆磷酸吡哆醛（PLP）浓度和出生体重是所检测的婴儿生长的最强预测指标。母乳和婴儿血浆中的碱性磷酸酶活性反映了这些液体中的吡哆醛-PLP比率，表明该酶在调节循环维生素浓度中起作用。
