Kasuya Y, Masuda Y, Shigenobu K
J Pharmacobiodyn. 1984 Feb;7(2):138-42. doi: 10.1248/bpb1978.7.138.
As the endothelium has an important role in the vasodilating effect of acetylcholine, we investigated the possible role of the endothelium in the vasodilating effect of platelet activating factor (PAF). Experiments were done on spirally cut rat thoracic aorta either containing or denuded of endothelial cells. It was demonstrated that relaxation by PAF and acetylcholine of pre-contracted strips required the presence of endothelial cells. The results strongly suggested the possible involvement of endothelium in the vasodilation produced by PAF as well as by ACh.
由于内皮细胞在乙酰胆碱的血管舒张作用中具有重要作用，我们研究了内皮细胞在血小板活化因子（PAF）血管舒张作用中的可能作用。实验在含有或去除内皮细胞的螺旋状切割大鼠胸主动脉上进行。结果表明，PAF和乙酰胆碱对预收缩条带的舒张作用需要内皮细胞的存在。结果强烈提示内皮细胞可能参与PAF以及ACh所产生的血管舒张作用。
