Green K F, Turner T T, Howards S S
J Urol. 1984 Jun;131(6):1208-11. doi: 10.1016/s0022-5347(17)50874-5.
An experimental left varicocele was created in the adult rat by partial ligation of the left renal vein. A varicocele repair was performed by high ligation of the internal spermatic vein. Testicular blood flow and temperature changes were measured in control and sham animals, animals 30 days after establishment of varicocele and animals 30 days after varicocele repair. There was a statistically significant (p less than or equal to 0.01) bilateral elevation of testicular blood flow and temperature in the varicocele group compared to control and sham groups. Varicocele repair returned these blood flow and temperature values to normal. Average testicular blood flow for control, varicocele, sham varicocele and varicocele repair animals were 29.6 +/- 1, 39.8 +/- 2, 30.7 +/- 1 and 29.8 +/- 1 ml. per min. per 100 gm. tissue, respectively. Testicular temperatures averaged 34.4 +/- 0.1, 35.3 +/- 0.2, 34.4 +/- 0.1 and 34.5 +/- 0.1 degrees C, respectively. It is possible that the elevation in blood flow is associated with the elevation of intratesticular temperature, which is known to impair spermatogenesis. The data support a relationship between the varicocele and potential testicular damage.
通过部分结扎左肾静脉在成年大鼠中制造实验性左侧精索静脉曲张。通过高位结扎精索内静脉进行精索静脉曲张修复。在对照动物、假手术动物、建立精索静脉曲张30天后的动物以及精索静脉曲张修复30天后的动物中测量睾丸血流和温度变化。与对照和假手术组相比，精索静脉曲张组的睾丸血流和温度在统计学上有显著的双侧升高（p小于或等于0.01）。精索静脉曲张修复使这些血流和温度值恢复正常。对照、精索静脉曲张、假手术精索静脉曲张和精索静脉曲张修复动物的平均睾丸血流分别为每分钟每100克组织29.6±1、39.8±2、30.7±1和29.8±1毫升。睾丸温度平均分别为34.4±0.1、35.3±0.2、34.4±0.1和34.5±0.1摄氏度。血流升高可能与睾丸内温度升高有关，已知睾丸内温度升高会损害精子发生。这些数据支持精索静脉曲张与潜在睾丸损伤之间的关系。
