Hurt G S, Howards S S, Turner T T
Department of Urology, University of Virginia Medical School, Charlottesville 22908.
J Androl. 1987 Nov-Dec;8(6):403-8. doi: 10.1002/j.1939-4640.1987.tb00988.x.
Unilateral varicocele has been associated with diminished male fertility in humans and with bilateral physiologic and histologic changes in the testis of humans and laboratory animals. In particular, left varicocele in Sprague-Dawley rats results in bilateral increases in testicular temperature and blood flow. The mechanism by which unilateral varicocele can cause testicular changes is not known. The purpose of the present study was to determine whether or not the presence of either the ipsilateral or contralateral testicle is necessary for these effects of the varicocele to occur in the opposite testis. Varicoceles were created in adult, male rats by partial constriction of the left renal vein. Bilateral testicular blood flow was measured by a radiolabelled microsphere distribution technique and testicular temperature was taken with a needle probe thermometer. Right or left orchiectomies were performed on selected animals at the time of surgery to establish the unilateral left varicocele. Animals were studied 30 days after surgery. Mean testicular blood flow was significantly increased (P less than 0.01) in all animals having a left varicocele when compared with animals not having a varicocele regardless of whether a unilateral orchiectomy was performed. Likewise, the mean difference between intraabdominal temperature and intratesticular temperature (delta T) was significantly decreased in all groups of animals having varicoceles when compared with groups without varicoceles whether or not an orchiectomy had been performed. Thus, the studied bilateral effects of left-sided, experimental varicocele in the rat are not dependent upon the presence of a left testicle.
单侧精索静脉曲张与人类男性生育能力下降以及人类和实验动物睾丸的双侧生理和组织学变化有关。特别是，斯普拉格-道利大鼠的左侧精索静脉曲张会导致双侧睾丸温度和血流量增加。单侧精索静脉曲张导致睾丸变化的机制尚不清楚。本研究的目的是确定精索静脉曲张对另一侧睾丸产生这些影响时，同侧或对侧睾丸的存在是否是必需的。通过部分结扎左肾静脉在成年雄性大鼠中制造精索静脉曲张。采用放射性微球分布技术测量双侧睾丸血流量，并用针式探头温度计测量睾丸温度。在手术时对选定的动物进行右侧或左侧睾丸切除术以建立单侧左侧精索静脉曲张。在手术后30天对动物进行研究。与没有精索静脉曲张的动物相比，所有患有左侧精索静脉曲张的动物，无论是否进行了单侧睾丸切除术，其平均睾丸血流量均显著增加（P<0.01）。同样，与没有精索静脉曲张的组相比，所有患有精索静脉曲张的动物组，无论是否进行了睾丸切除术，其腹腔内温度与睾丸内温度之差（ΔT）均显著降低。因此，大鼠左侧实验性精索静脉曲张的双侧影响并不依赖于左侧睾丸的存在。
