Turner T T, Lopez T J
Department of Urology, University of Virginia Health Sciences Center, Charlottesville.
J Urol. 1990 Oct;144(4):1018-21. doi: 10.1016/s0022-5347(17)39650-7.
Testicular and reference organ blood flows and testicular temperatures were determined in peripubertal and mature rats with and without experimental left varicocele (ELV). Testicular blood flow and temperature were significantly increased bilaterally 30 days after surgery to induce unilateral varicocele, and this was the case in both the younger and older animals. It has not previously been known that the pathophysiological effects of ELV extended to the peripubertal testis. Previous experiments have demonstrated that the left testis is not necessary for the right testicular response to varicocele. In the present paper, animals were subjected to left orchiectomy simultaneously with the surgery to induce ELV. Thirty days later, the animals were divided into those with and those without the left spermatic vein varicosity. Testicular blood flow was determined in all these animals as well as in a separate group of control and experimental varicocele animals. The group of ELV animals with left spermatic varicosity demonstrated a significant increase in contralateral testicular blood flow while the ELV group without left spermatic varicosity did not. We speculate that left venous distention is involved in the mechanism for the contralateral response to unilateral varicocele.
在青春期前和成熟大鼠中，分别测定了有无实验性左侧精索静脉曲张（ELV）时睾丸及参照器官的血流情况和睾丸温度。在诱导单侧精索静脉曲张手术后30天，双侧睾丸的血流和温度均显著升高，无论年幼或年长动物均是如此。此前尚不清楚ELV的病理生理效应是否会扩展至青春期前睾丸。先前的实验表明，右侧睾丸对精索静脉曲张的反应并不依赖左侧睾丸。在本文中，动物在诱导ELV手术的同时接受左侧睾丸切除术。30天后，将动物分为有和没有左侧精索静脉曲张两组。测定了所有这些动物以及另一组对照和实验性精索静脉曲张动物的睾丸血流情况。有左侧精索静脉曲张的ELV动物组对侧睾丸血流显著增加，而无左侧精索静脉曲张的ELV组则未出现这种情况。我们推测，左侧静脉扩张参与了对单侧精索静脉曲张对侧反应的机制。
