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四种主动脉瓣假体产生的反流程度的比较研究。

Comparative study of the amount of backflow produced by four types of aortic valve prostheses.

作者信息

Sabbah H N, Stein P D

出版信息

J Biomech Eng. 1984 Feb;106(1):66-71. doi: 10.1115/1.3138459.

Abstract

To determine the extent of backflow encountered with currently used prosthetic valves, four types of aortic valves with comparable orifice diameters were tested in a pulse duplicating system. These were a Hancock porcine valve, a Lillehei-Kaster pivoting disk valve, a St. Jude bileaflet valve and a Björk-Shiley tilting disk valve. Mean aortic pressure was sequentially increased from 83 to 147 mmHg, keeping the pump rate essentially constant (69-73 strokes/min). The porcine valve produced the least amount of total backflow (backflow due to closure plus leakage backflow) (1.6 to 2.4 mL/stroke). Among the mechanical valves the Björk-Shiley valve showed the least amount of total backflow (5.0 to 6.0 mL/stroke). At a mean aortic pressure of 100 mmHg and a low cardiac output of 2 L/min, the total backflow with the porcine valve was only 6 percent of forward flow; whereas it was 19 percent with the Lillehei-Kaster valve, 22 percent with the St. Jude valve and 18 percent with the Björk-Shiley valve. Leakage backflow at a given level of mean aortic pressure was, as expected, directly related to the annular clearance area. It is concluded that the Hancock valve showed the least amount of backward flow, which would be particularly beneficial in low output states. In the presence of normal hemodynamics, the amount of backflow with the three mechanical valves appeared to be well below the level of backflow considered to be clinically significant.

摘要

为了确定当前使用的人工瓣膜所遇到的反流程度,在脉动复制系统中对四种具有可比孔径的主动脉瓣进行了测试。这些瓣膜分别是汉考克猪瓣膜、 Lillehei-Kaster 旋转盘瓣、圣犹达双叶瓣和 Björk-Shiley 倾斜盘瓣。平均主动脉压力从 83 mmHg 依次增加到 147 mmHg ,同时保持泵速基本恒定( 69 - 73 次 / 分钟)。猪瓣膜产生的总反流(关闭引起的反流加上漏流反流)量最少( 1.6 至 2.4 mL/ 次搏动)。在机械瓣膜中, Björk-Shiley 瓣膜的总反流最少( 5.0 至 6.0 mL/ 次搏动)。在平均主动脉压力为 100 mmHg 且心输出量较低为 2 L/ 分钟时,猪瓣膜的总反流仅为前向血流的 6% ;而 Lillehei-Kaster 瓣膜为 19% ,圣犹达瓣膜为 22% , Björk-Shiley 瓣膜为 18% 。在给定平均主动脉压力水平下的漏流反流,正如预期的那样,与瓣环间隙面积直接相关。得出的结论是,汉考克瓣膜的反流最少,这在低输出状态下将特别有益。在正常血流动力学情况下,三种机械瓣膜的反流似乎远低于被认为具有临床意义的反流水平。

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