Spencer R J, Melton L J, Ready R L, Ilstrup D M
Mayo Clin Proc. 1984 May;59(5):305-10. doi: 10.1016/s0025-6196(12)61425-6.
We conducted a retrospective cohort study of 751 residents of Rochester, Minnesota, whose small (1 cm or less) colorectal polyps had been treated without biopsy. Eighteen colorectal carcinomas were found in this group in the course of more than 10,000 person-years of follow-up, whereas 15.27 cases were expected (relative risk, 1.2). The overall rate for the development of cancer and the relative risks for various subgroups of the cohort were not significantly elevated, and survival in this cohort was not impaired. We conclude that fulguration of selected small colorectal polyps without prior biopsy does not subject patients to an unusual risk for development of colorectal carcinoma. Customary periodic medical examination should suffice for patients with these lesions.
我们对明尼苏达州罗切斯特市的751名居民进行了一项回顾性队列研究，这些居民的小（1厘米或更小）结直肠息肉未经活检就接受了治疗。在超过10000人年的随访过程中，该组发现了18例结直肠癌，而预期为15.27例（相对风险为1.2）。该队列中癌症发生的总体率以及各个亚组的相对风险没有显著升高，并且该队列中的生存率也没有受损。我们得出结论，对选定的小结直肠息肉进行电灼而不进行事先活检不会使患者面临结直肠癌发生的异常风险。对于患有这些病变的患者，常规的定期体检应该就足够了。
