Kronborg O, Fenger C
Department of Surgical Gastroenterology, Odense University Hospital, Denmark.
Int J Colorectal Dis. 1987 Nov;2(4):203-7. doi: 10.1007/BF01649506.
Between 1978 and 1986 colorectal adenomas without invasion were removed in 552 patients under 76 years of age. Patients were randomly allocated to different follow-up groups with intervals of colorectal examination varying from 6 to 48 months after the initial polypectomy. A large bowel carcinoma developed in three patients and new adenomas in 87 patients. Based on the morphology of the initial adenomas possible relationships between prognostic factors and the risk of new adenoma formation were assessed using life-table analysis. The advantage of a possible decrease in the risk of developing carcinoma was offset by the disadvantage of eight severe complications occurring in 1818 colonoscopies, one of which proved fatal. The occurrence of one of the three carcinomas was considered a failure of the follow-up programme.
1978年至1986年间，对552名76岁以下无浸润性的大肠腺瘤患者进行了切除手术。患者被随机分配到不同的随访组，初次息肉切除术后大肠检查间隔时间从6个月到48个月不等。3名患者发生了大肠癌，87名患者出现了新的腺瘤。根据最初腺瘤的形态，采用生命表分析评估预后因素与新腺瘤形成风险之间的可能关系。1818次结肠镜检查中出现8例严重并发症（其中1例死亡），抵消了患癌风险可能降低的优势。3例癌症中有1例的发生被认为是随访计划的失败。
