Katz M L, Robison W G, Herrmann R K, Groome A B, Bieri J G
Mech Ageing Dev. 1984 Apr-May;25(1-2):149-59. doi: 10.1016/0047-6374(84)90137-4.
The corrected fluorescence emission spectra and tissue distributions of the autofluorescent pigments which accumulate during normal aging and as a consequence of vitamin E deficiency were studied in albino rats. In the retinal pigment epithelium, both the age-related pigment (lipofuscin) and the pigment related to vitamin E deficiency had essentially identical emission spectra. Peak emission occurred from 590 to 650 nm. Young animals which had been kept on a vitamin E deficient diet for 17 weeks after weaning showed significant accumulations of autofluorescent pigment in uterus, duodenum, and retinal pigment epithelium, but not in the spinal cord or inferior olivary nucleus of the brain. Old animals (96 weeks) fed a commercial diet with adequate vitamin E had accumulated lipofuscin in the retinal pigment epithelium, spinal cord gray matter, and inferior olivary nucleus, but not in the duodenum or uterus. Thus, while the auto-fluorescent pigments related to aging and vitamin E deficiency have similar properties, their tissue distributions are quite different.
在白化大鼠中研究了正常衰老过程中以及维生素E缺乏时积累的自发荧光色素的校正荧光发射光谱和组织分布。在视网膜色素上皮中，与年龄相关的色素（脂褐素）和与维生素E缺乏相关的色素具有基本相同的发射光谱。峰值发射出现在590至650nm之间。断奶后在维生素E缺乏饮食中饲养17周的幼龄动物，在子宫、十二指肠和视网膜色素上皮中出现了自发荧光色素的显著积累，但在脊髓或脑的下橄榄核中未出现。喂食含有充足维生素E的商业饮食的老龄动物（96周），在视网膜色素上皮、脊髓灰质和下橄榄核中积累了脂褐素，但在十二指肠或子宫中未积累。因此，虽然与衰老和维生素E缺乏相关的自发荧光色素具有相似的特性，但它们的组织分布却大不相同。
