膳食维生素E和衰老对小鼠组织脂褐素色素浓度的影响。

Effect of dietary vitamin E and aging on tissue lipofuscin pigment concentration in mice.

作者信息

Csallany A S, Ayaz K L, Su L C

出版信息

J Nutr. 1977 Oct;107(10):1792-9. doi: 10.1093/jn/107.10.1792.

DOI:10.1093/jn/107.10.1792

Abstract

This study reports a re-investigation of the effect of dietary vitamin E upon tissue organic solvent soluble lipofuscin pigment concentrations. Female weanling mice were fed a vitamin E deficient, vitamin E or N,N'-diphenyl-phenylenediamine (DPPD) supplemented diet up to 18 months of age. Lipofuscin concentrations were measured by a quantitative method which is based on fluorescence spectroscopy. Of all tissues measured (uterus, lung, spleen, kidney, liver, heart and brain), only the liver responded and showed lower pigment concentrations due to vitamin E treatment. In addition, in the liver, up to 12 months of age, vitamin E supplementation resulted in gradually decreasing pigment concentrations, but by 18 months of age, pigment concentrations were increased by 5 to 10 times in all diet groups. The effect of DPPD was similar to vitamin E. Tissue lipofuscin pigment concentrations in 18-month-old mice were lowest in the uterus and highest in the heart. The data indicate the possibility of a turnover of the organic solvent soluble lipofuscin pigments in the liver.

摘要

本研究报告了对膳食维生素E对组织有机溶剂可溶性脂褐素色素浓度影响的重新调查。将雌性断奶小鼠喂食缺乏维生素E、补充维生素E或N,N'-二苯基-对苯二胺（DPPD）的饮食，直至18个月龄。通过基于荧光光谱的定量方法测量脂褐素浓度。在所有测量的组织（子宫、肺、脾、肾、肝、心和脑）中，只有肝脏有反应，并且由于维生素E处理而显示出较低的色素浓度。此外，在肝脏中，到12个月龄时，补充维生素E导致色素浓度逐渐降低，但到18个月龄时，所有饮食组的色素浓度增加了5至10倍。DPPD的作用与维生素E相似。18个月龄小鼠的组织脂褐素色素浓度在子宫中最低，在心脏中最高。数据表明肝脏中有机溶剂可溶性脂褐素色素存在周转的可能性。