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[青少年鼻咽纤维瘤。经验报告]

[Juvenile nasopharyngeal fibroma. Report of experiences].

作者信息

Weidenbecher M

出版信息

Laryngol Rhinol Otol (Stuttg). 1984 Apr;63(4):184-8.

PMID:6727499
Abstract

The juvenile nasopharyngeal angiofibroma is a rare and histologically benign tumour of the adolescent male. The aetiology and site of origin are unknown. The diagnosis can easily be made by the symptoms, the typical angiographic pattern and the endoscopic picture. Complete surgical extirpation is superior to all other modalities such as radiotherapy and hormonal treatment. To reduce the enormous blood flow into the tumour, the ligation of the external carotid artery, or the embolisation of the feeding vessels are the best presurgical methods. The technique of tumour removal differs according to the size of the tumour. A great therapeutic problem are those tumours which grow through the skull base and invade the sella, the optic nerve or the cavernous sinus. These tumours should be removed as radically as possible. Small areas of intracranial tumour could remain in order to preserve the optic nerve or the pituitary. These small areas respond very well to 4000 rads. Of 14 patients treated between 1972 and 1981, 12 tumours (types I and II) could be removed completely (recurrence rate 0%), 2 neoplasms ( typ III and IV) which were removed incompletely, received 4000 rads directed at the intracranial remnant, and showed no tumour progression within 4 and 6 years. The preoperative use of hormones (2 cases) showed no effect on the tumour size, especially not on intraoperative loss of blood.

摘要

青少年鼻咽血管纤维瘤是一种罕见的、组织学上为良性的青少年男性肿瘤。其病因和起源部位尚不清楚。通过症状、典型的血管造影模式和内镜图像很容易做出诊断。完整的手术切除优于所有其他治疗方式,如放疗和激素治疗。为减少肿瘤内大量的血流,结扎颈外动脉或栓塞供血血管是最佳的术前方法。肿瘤切除技术因肿瘤大小而异。一个重大的治疗难题是那些穿过颅底并侵犯蝶鞍、视神经或海绵窦的肿瘤。这些肿瘤应尽可能彻底地切除。为了保留视神经或垂体,可以残留小面积的颅内肿瘤。这些小面积肿瘤对4000拉德的放疗反应良好。在1972年至1981年期间治疗的14例患者中,12例肿瘤(I型和II型)能够完全切除(复发率0%),2例肿瘤(III型和IV型)切除不完全,对颅内残留部分给予4000拉德的放疗,在4年和6年内未显示肿瘤进展。术前使用激素(2例)对肿瘤大小没有影响,尤其是对术中失血没有影响。

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