Economou T S, Abemayor E, Ward P H
Jonsson Comprehensive Cancer Center, UCLA School of Medicine 90024-1624.
Laryngoscope. 1988 Feb;98(2):170-5. doi: 10.1288/00005537-198802000-00010.
The UCLA experience with juvenile angiofibroma (JNA) over a 25-year period is reviewed. There were 83 patients, the majority being adolescent males. Surgery was the primary method of treatment for disease not extending intracranially; 63 of 68 patients (92.5%) became asymptomatic with this modality. In patients treated with a single course of primary radiation, 10 of 14 (78.5%) became asymptomatic. Trends in diagnosis and treatment were evaluated. Contrast computerized tomography reliably assesses tumor extent. Preoperative arteriography is essential for the evaluation and embolization of feeding vessels; this in turn significantly reduces operative blood loss and the need for transfusions. Radiotherapy should be reserved for disease extending intracranially and should be in doses of 3,600 cGy or larger.
回顾了加州大学洛杉矶分校在25年期间对青少年血管纤维瘤（JNA）的治疗经验。共有83例患者，大多数为青少年男性。对于未向颅内扩展的疾病，手术是主要的治疗方法；68例患者中有63例（92.5%）通过这种方式达到无症状状态。在接受单一疗程原发性放疗的患者中，14例中有10例（78.5%）达到无症状状态。评估了诊断和治疗的趋势。增强计算机断层扫描能够可靠地评估肿瘤范围。术前动脉造影对于供血血管的评估和栓塞至关重要；这反过来又显著减少了术中失血和输血需求。放疗应保留用于向颅内扩展的疾病，剂量应为3600厘戈瑞或更大。
