Hsiao S, Katsuura G, Itoh S
Life Sci. 1984 May 28;34(22):2165-8. doi: 10.1016/0024-3205(84)90316-3.
The effect of cholecystokinin tetrapeptide (CCK-4) was studied in an open field situation. CCK-4 increased locomotion and rearing and the effect was enhanced by proglumide, a selective antagonist of CCK-8. This is in sharp contrast to our earlier findings that CCK-8 decreased the open-field behavior and that proglumide completely blocked the effect. Thus, the effects of CCK-4 and CCK-8 appear to be opposite to each other in that one is excitatory and the other inhibitory to open-field responses.
在旷场实验情境中研究了胆囊收缩素四肽（CCK - 4）的作用。CCK - 4增加了活动和直立行为，且该作用被CCK - 8的选择性拮抗剂丙谷胺增强。这与我们早期的发现形成鲜明对比，即CCK - 8降低旷场行为，且丙谷胺完全阻断了该作用。因此，CCK - 4和CCK - 8的作用似乎彼此相反，因为一个对旷场反应起兴奋作用，另一个起抑制作用。
