Pritz W F, Mitterauer B J
Psychopathology. 1984;17(2):67-79. doi: 10.1159/000284006.
The study uses the 'affected (and hospitalized) siblings method' to investigate aspects of correlation in the psychopathology of bipolar mood disorders. In part one, age of onset, duration of phases, and course of illness are the points of interest. The sample includes 307 sibling groups (701 hospitalized individuals). The incidence of pure or schizoaffective type mania in at least 1 sibling has been the criterion for selection. The genetic background is also presented and the question is raised whether double tainting is the rule rather than the exception. The hypothesis that schizophrenic syndromes and mood disorders develop from separate genetic pools is supported. Strong evidence against the unipolar/bipolar dichotomy is presented. The investigation brings the breadth of the cyclothymic spectrum and inhomogeneity with respect to the course of bipolar disorders into perspective.
该研究采用“受影响（且住院）的兄弟姐妹方法”来调查双相情感障碍心理病理学中的相关性。在第一部分中，发病年龄、各阶段持续时间和病程是关注重点。样本包括307个兄弟姐妹组（701名住院个体）。选择标准是至少有1名兄弟姐妹患有纯躁狂或精神分裂症性躁狂。文中还呈现了遗传背景，并提出双相污染是否是规律而非例外的问题。支持精神分裂症综合征和情感障碍源自不同基因库的假说。提出了反对单极/双极二分法的有力证据。该调查揭示了环性心境障碍谱的广度以及双相情感障碍病程的不均一性。
