Baron M, Risch N, Mendlewicz J
J Psychiatr Res. 1982;17(1):5-18. doi: 10.1016/0022-3956(82)90030-9.
Age-of-onset data were collected on 142 bipolar probands (61 males, 81 females) and 110 siblings. After correcting for demographic factors the age at illness onset did not distinguish bipolar from unipolar siblings or siblings from probands. This indicates that in a subset of pedigree data, bipolar and unipolar affective disorders may be different phenotypic manifestations of the same underlying disorder. A total of 43% of affected individuals gave evidence of illness before age 30 and 11% were ill as adolescents. Also 2% were affected prior to age 15. The data indicate that affective illness is not uncommon in adolescence and may occur as a childhood disorder. Estimation of the age-of-onset probability distribution was obtained by incorporating demographic factors (survivorship data) into the observed ages at onset of affected individuals. A square-root normal curve fits the age-of-onset probability density function. The implications for morbid risk prediction and genetic analysis of affective disorders were discussed.
收集了142名双相情感障碍先证者（61名男性，81名女性）和110名同胞的发病年龄数据。校正人口统计学因素后，发病年龄无法区分双相情感障碍同胞与单相情感障碍同胞，也无法区分同胞与先证者。这表明，在一部分家系数据中，双相情感障碍和单相情感障碍可能是同一潜在疾病的不同表型表现。共有43%的受影响个体在30岁之前发病，11%在青少年期发病。还有2%在15岁之前就受到影响。数据表明，情感障碍在青少年中并不罕见，也可能在儿童期发病。通过将人口统计学因素（生存数据）纳入受影响个体的观察发病年龄，获得了发病年龄概率分布的估计值。平方根正态曲线拟合发病年龄概率密度函数。文中讨论了其对情感障碍发病风险预测和遗传分析的意义。
