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硼和氮中中子俘获反应在V79中国仓鼠细胞中的相对生物效应。

The relative biological effectiveness in V79 Chinese hamster cells of the neutron capture reactions in boron and nitrogen.

作者信息

Gabel D, Fairchild R G, Larsson B, Börner H G

出版信息

Radiat Res. 1984 May;98(2):307-16.

PMID:6729040
Abstract

V79 Chinese hamster cells were irradiated in the presence of different amounts of boric acid with thermal neutrons at the Medical Research Reactor at Brookhaven National Laboratory. From the linear dose-survival curves observed, a D0 value of 66 rad for the 10B(n, alpha) 7Li neutron capture reaction was obtained. No dependence of this value on the concentration of boric acid was found. Comparing this value to the D0 value of 150 rad obtained with 250 kVp X rays between 10 and 0.01% survival, an extrapolated RBE value of 2.3 was calculated. By irradiation of the same line of cells with cold neutrons at the Institut Laue - Langevin , a D0 value for the 14N(n,p)14C reaction of 77 rad was obtained, with a corresponding RBE value of 1.9. Comparison is made with previously published RBE values for the 10B(n, alpha) 7Li reaction.

摘要

V79中国仓鼠细胞在布鲁克海文国家实验室的医学研究反应堆中,于不同硼酸含量存在的情况下接受热中子辐照。从观察到的线性剂量存活曲线可知,对于10B(n,α)7Li中子俘获反应,获得的D0值为66拉德。未发现该值与硼酸浓度存在相关性。将此值与在10%至0.01%存活率之间用250 kVp X射线获得的150拉德的D0值进行比较,计算得出外推的相对生物效应(RBE)值为2.3。通过在劳厄 - 郎之万研究所用冷中子辐照同一细胞系,获得了14N(n,p)14C反应的D0值为77拉德,相应的RBE值为1.9。文中还与先前发表的关于10B(n,α)7Li反应的RBE值进行了比较。

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