Volpe B T, Pulsinelli W A, Tribuna J, Davis H P
Stroke. 1984 May-Jun;15(3):558-62. doi: 10.1161/01.str.15.3.558.
Rats subjected to transient forebrain ischemic injury by the method of four vessel occlusion (4-VO) develop irreversible injury to select populations of vulnerable neurons which include pyramidal cells in the CA-1 region of the hippocampus. This brain area is thought to be crucial for learning and memory. Rats subjected to 30 minutes of 4-VO, and then cerebral reperfusion were tested on a radial 8-arm maze task after they had recovered. The data shows that both 4-VO and control animals improve their performance over trials, but that 4-VO rats are impaired on "working" and "reference" tasks. The data suggest that 4-VO rats' impaired "working" performance is permanent, compared to their transient "reference" impairment. Alterations in sensorimotor activity could not account for these performance deficits since control and 4-VO rats demonstrated equivalent choice time per maze arm. Performance deficits in rats following forebrain ischemic injury may be similar to some of the cognitive deficits found in humans survivors of cerebral hypoxia-ischemia.
通过四血管闭塞（4-VO）方法遭受短暂性前脑缺血损伤的大鼠，其特定易损神经元群体，包括海马体CA-1区的锥体细胞，会出现不可逆损伤。这个脑区被认为对学习和记忆至关重要。遭受30分钟4-VO然后进行脑再灌注的大鼠，恢复后在放射状8臂迷宫任务中接受测试。数据显示，4-VO组和对照组动物在多次试验中都提高了它们的表现，但4-VO组大鼠在“工作”和“参考”任务中受损。数据表明，与短暂的“参考”损伤相比，4-VO组大鼠“工作”表现的损伤是永久性的。感觉运动活动的改变不能解释这些表现缺陷，因为对照组和4-VO组大鼠在每个迷宫臂上的选择时间相当。前脑缺血损伤后大鼠的表现缺陷可能与脑缺氧缺血人类幸存者中发现的一些认知缺陷相似。
