Ali B H, Hassan T, Wasfi I A, Mustafa A I
Vet Hum Toxicol. 1984 Jun;26(3):197-200.
Male Nubian goats were given furazlidone orally at daily doses of 40, 80, 160 and 320 mg/kg for up to 10 days. Animals given 160 and 320 mg/kg became anemic, and showed anorexia, hyperexcitability, uneasiness , backward walking, locomotory disturbances and circling. These animals died within 5 to 7 days of treatment. Postmortem examination showed mild congestion in brain, and fatty change in liver and kidneys. There was histopathological evidence of hepatic and renal damage, and some necrosis in brain and adrenals. Biochemical examination of serum confirmed the presence of hepatic and renal damage. Goats given furazolidone at daily doses of 40 and 80 mg/kg showed similar signs as above, but to a lesser degree. They were killed at the end of the experiment (10 days). The signs of furazolidone intoxication resembled those of cerebrocortical necrosis (thiamine deficiency in ruminants). Therefore, thiamine (100 mg/animal) was injected iv daily to goats receiving 320 mg furazolidone/kg. The vitamin ameliorated the severity of the drug toxicity.
给雄性努比亚山羊口服呋喃唑酮，日剂量分别为40、80、160和320毫克/千克，持续给药长达10天。给予160和320毫克/千克剂量的动物出现贫血，并表现出厌食、过度兴奋、不安、倒退行走、运动障碍和转圈。这些动物在治疗后5至7天内死亡。尸检显示脑部轻度充血，肝脏和肾脏出现脂肪变性。有组织病理学证据表明肝脏和肾脏受损，脑部和肾上腺有一些坏死。血清生化检查证实存在肝脏和肾脏损伤。给予日剂量40和80毫克/千克呋喃唑酮的山羊表现出与上述相似的症状，但程度较轻。它们在实验结束时（10天）被处死。呋喃唑酮中毒的症状类似于脑皮质坏死（反刍动物硫胺素缺乏）。因此，每天给接受320毫克呋喃唑酮/千克的山羊静脉注射硫胺素（100毫克/只）。该维生素减轻了药物毒性的严重程度。
