Malenko G V, Pogodina V V, Karmysheva V Ia
Vopr Virusol. 1984 Mar-Apr;29(2):217-23.
The effect of streptomycin (C) on persistence of tick-borne encephalitis (TBE) virus in Syrian hamsters infected with 3 strains of the virus (41/65, Aina/1448, Vasilchenko ) intracerebrally or subcutaneously was studied. In the animals not given C the infectious virus could be detected in the brain for 8-14 days but not later although their organs (mostly brains and spleens) contained the hemagglutinating antigen and viral antigen detectable by immunofluorescence. Intramuscularly C was given twice daily for 13-35 days in a daily dose of 200 mg/kg. The C-treated hamsters yielded 7 virulent TBE virus strains: 3 from the brain, 3 from the spleen, and one from the blood. No virus could be isolated from the liver, kidneys, or lungs despite the use of various methods for isolation including tissue explantation. The activating effect of C was observed against the background of 4-fold decrease in the titre of complement-fixing and antihemagglutinating antibodies. C exerted its activating effect both at early (70 days) and late (9 months) stages of TBE virus persistence. The activating effect of C appears to be due to its immunosuppressive properties and neurotoxic action on the CNS.
研究了链霉素（C）对经脑内或皮下感染3株蜱传脑炎（TBE）病毒（41/65、艾娜/1448、瓦西里琴科）的叙利亚仓鼠体内TBE病毒持续存在的影响。在未给予C的动物中，可在脑内检测到感染性病毒达8 - 14天，但此后则检测不到，尽管其器官（主要是脑和脾）含有血凝抗原和可通过免疫荧光检测到的病毒抗原。肌肉注射C，每日2次，持续13 - 35天，日剂量为200 mg/kg。接受C治疗的仓鼠产生了7株强毒TBE病毒株：3株来自脑，3株来自脾，1株来自血液。尽管使用了包括组织外植等各种分离方法，但从肝脏、肾脏或肺中均未分离到病毒。在补体结合抗体和抗血凝抗体滴度下降4倍的背景下，观察到了C的激活作用。C在TBE病毒持续存在的早期（70天）和晚期（9个月）均发挥了激活作用。C的激活作用似乎归因于其免疫抑制特性以及对中枢神经系统的神经毒性作用。
