Frolova T V, Frolova M P, Pogodona V V, Sobolev S G, Karmysheva V Ia
Zh Nevropatol Psikhiatr Im S S Korsakova. 1987;87(2):170-8.
A long-term experiment was conducted to study various aspects of the pathogenesis of persistent and chronic tick-borne encephalitis (TBE). Virological, serological, pathomorphological, electron microscopic and immunofluorescent techniques have been utilized in this study. Persistent TBE infection of Syrian hamsters examined over the period from 40 days to 2 years was characterized by the presence of virus-specific antigens in the organs and of specific antibodies in the blood serum. The persisting TBE virus was found to be predominantly localized in the central nervous system and spleen. Nerve cells underwent ultrastructural changes which were characteristic of flavivirus infection and related to the morphogenesis of viral particles. The authors have developed an experimental model of a primary progressive form of TBE with early and late manifestations of clinical symptoms of the disease.
开展了一项长期实验，以研究持续性和慢性蜱传脑炎（TBE）发病机制的各个方面。本研究采用了病毒学、血清学、病理形态学、电子显微镜和免疫荧光技术。对叙利亚仓鼠进行了长达40天至2年的持续性TBE感染检测，其特征是器官中存在病毒特异性抗原，血清中存在特异性抗体。发现持续存在的TBE病毒主要定位于中枢神经系统和脾脏。神经细胞发生了超微结构变化，这是黄病毒感染的特征，并且与病毒颗粒的形态发生有关。作者建立了一种TBE原发性进行性形式的实验模型，该模型具有该疾病临床症状的早期和晚期表现。
