Penkov N, Penev A, Kaponov Kh
Vutr Boles. 1984;23(1):63-9.
The antiarrhythmic effect of isoptin was verified in 47 patients--30 with paroxysmal supraventricular tachycardia and 17--with paroxysmal ventricular fibrillation: in case of paroxysmal supraventricular tachycardia with 5--10 mg isoptin i.v. for the restoration of sinus rhythm and with 240--320 mg orally for maintaining the effect and in case of ventricular fibrillation--i. v. for the slowing down the heart rate. Isoptin, i. v. applied, restores the sinus rhythm in 93,3 per cent of the patients with paroxysmal supraventricular tachycardia and in 17,6 per cent--with ventricular fibrillation and slowsdown the heart rate in 94,6 per cent among those with ventricular fibrillation. The oral isoptin reduces the paroxysms of the supraventricular tachycardia in 86 per cent and slowsdown the sinus rate and lengthens PQ.
47例患者验证了异搏定的抗心律失常作用,其中30例阵发性室上性心动过速患者和17例阵发性心室颤动患者:对于阵发性室上性心动过速,静脉注射5 - 10mg异搏定恢复窦性心律,口服240 - 320mg维持疗效;对于心室颤动,静脉注射以减慢心率。静脉注射异搏定可使93.3%的阵发性室上性心动过速患者恢复窦性心律,使17.6%的心室颤动患者恢复窦性心律,并使94.6%的心室颤动患者心率减慢。口服异搏定可使86%的室上性心动过速发作减少,并减慢窦性心率,延长PQ间期。