Werner H, Matuschka F R, Brandenburg I
Zentralbl Bakteriol Orig A. 1979 Oct;245(1-2):240-53.
Mastomys natalensis chronically infected with Toxoplasma gondii strain ALT over two months were treated with sulfamethoxypyrazine-pyrimethamine for 10 and 25 days. 72 hours after discontinuation of therapy the animals were sacrificed. The brains were removed and, following corresponding preparation, studied for the presence of the parasite and structural changes of cysts by light and transmission electron microscopy. More or less pronounced structural changes could be found in cyst walls, bradyzoites, and in particular in the endodyogeny stages. The degree of damage proved to be proportional to the intensity of the bradyzoite metabolism. The combination of drugs used was capable of passing the cyst membrane as long as the bradyzoites maintained their metabolism irrespective of its intensity. In cysts with a largely dormant metabolism that had been subject to therapy, no micromorphological differences of the ultrastructure could be recognized when compared with untreated controls of identical age; these cysts could not be influenced by treatment.
对感染刚地弓形虫ALT株超过两个月的南非多乳鼠用磺胺甲氧嗪-乙胺嘧啶治疗10天和25天。停药72小时后处死动物。取出大脑，经过相应处理后，通过光学显微镜和透射电子显微镜研究寄生虫的存在以及包囊的结构变化。在包囊壁、缓殖子中，特别是在内二殖发育阶段可发现或多或少明显的结构变化。损伤程度与缓殖子代谢强度成正比。只要缓殖子保持其代谢，无论代谢强度如何，所用药物组合都能够穿过包囊膜。在代谢基本处于休眠状态且接受过治疗的包囊中，与相同年龄的未治疗对照相比，超微结构没有微观形态学差异；这些包囊不受治疗影响。
