Elmgreen J, Sørensen H, Berkowicz A
Acta Med Scand. 1984;215(4):375-8. doi: 10.1111/j.0954-6820.1984.tb05021.x.
Polymorphism of the third component of complement (C3), occupying a key position in cascade reactions, was investigated in 125 consecutive outpatients, 53 with Crohn's disease and 72 with ulcerative colitis. A sample of 1378 randomly selected healthy volunteers of Danish origin served as controls. Occurrence of the F and FS phenotype of C3 (C3F and C3FS ) was increased in the group of Crohn's disease patients (chi 2 = 2.80, p less than 0.05, one-tailed test) and in a subgroup of Crohn patients with the gastrointestinal disease process confined to ileum (chi 2 = 6.91, p less than 0.01). C3 phenotype distribution was unaffected in ulcerative colitis. Only S and F alleles of C3 ( C3S and C3F) were recognized and C3F frequencies were 0.33 in Crohn patients with small bowel disease, 0.23 in all Crohn patients, 0.18 in ulcerative colitis patients and 0.17 in healthy volunteers. The results are compatible with a positive association of the C3F gene and Crohn's disease located in the small bowel.
补体第三成分（C3）在级联反应中占据关键位置，对125例连续门诊患者进行了研究，其中53例患有克罗恩病，72例患有溃疡性结肠炎。选取1378名随机挑选的丹麦裔健康志愿者作为对照。C3的F和FS表型（C3F和C3FS）在克罗恩病患者组中出现频率增加（卡方=2.80，p<0.05，单尾检验），在胃肠道疾病局限于回肠的克罗恩病患者亚组中也增加（卡方=6.91，p<0.01）。溃疡性结肠炎患者的C3表型分布未受影响。仅识别出C3的S和F等位基因（C3S和C3F），小肠疾病的克罗恩病患者中C3F频率为0.33，所有克罗恩病患者中为0.23，溃疡性结肠炎患者中为0.18，健康志愿者中为0.17。结果表明C3F基因与小肠克罗恩病呈正相关。
