Ross I N, Thompson R A, Montgomery R D, Asquith P
J Clin Pathol. 1979 Aug;32(8):798-801. doi: 10.1136/jcp.32.8.798.
Levels of the serum complement components, C3 and C4, in patients with Crohn's disease, ulcerative colitis, and miscellaneous gastrointestinal disorders were compared with those of normal blood donors. Significant increases of both components were found in all three patient groups, the highest being in patients with Crohn's disease. Generally, levels of C3 and C4 were lower in patients with inactive rather than active Crohn's disease and ulcerative colitis. These results provide some evidence in support of an immunological basis for inflammatory bowel disease. However, in view of the frequent elevation of C3 and C4 in other gastrointestinal diseases, it is equally possible that the complement components are behaving as acute phase proteins.
将克罗恩病、溃疡性结肠炎及其他各类胃肠道疾病患者的血清补体成分C3和C4水平，与正常献血者的水平进行了比较。在所有三组患者中均发现这两种成分显著升高，其中克罗恩病患者升高幅度最大。一般而言，克罗恩病和溃疡性结肠炎非活动期患者的C3和C4水平低于活动期患者。这些结果为炎症性肠病的免疫学基础提供了一些证据。然而，鉴于其他胃肠道疾病中C3和C4也经常升高，补体成分表现为急性期蛋白的可能性同样存在。
