Tagami H, Sunami A, Akagi M, Tasaka K
Agents Actions. 1984 Apr;14(3-4):538-42. doi: 10.1007/BF01973866.
Histamine produced an excitatory effect on CA3 pyramidal cells in hippocampal slices of guinea-pigs. The amplitude of population spikes and EPSPs was augmented by histamine at concentrations of 10(-7) to 10(-6) M. Cimetidine but not pyrilamine prevented the stimulatory effect. The histamine effect was mimicked by dimaprit but not by 2-pyridylethylamine. It is concluded that histamine has a facilitatory influence on the hippocampal excitatory system via H2 receptor.
组胺对豚鼠海马切片中的CA3锥体细胞产生兴奋作用。在浓度为10^(-7)至10^(-6) M时，组胺增强了群体峰电位和兴奋性突触后电位的幅度。西咪替丁而非吡苄明可阻止这种刺激作用。二甲双胍可模拟组胺的作用，而2-吡啶乙胺则不能。结论是组胺通过H2受体对海马兴奋性系统有促进作用。
