Yoshimoto T, Sakamoto T, Watanabe T, Tanaka S, Suzuki J
No Shinkei Geka. 1978 Jun;6(6):539-41.
One day during an aneurysm surgery under the preoperative administration of mannitol, the feeding artery was accidentally occluded temporarily. Since then, investigation on whether or not mannitol can prevent infarctions in ischemic brain tissues have been carried out utilizing the thalamus infarction model in dogs. Twenty dogs were divided into equal groups, the control and the mannitol group. Temporary clipping for sixty minutes was adopted as a standard for both groups. The only difference between the groups was the administration of 2 g/kg of mannitol before the arterial occlusions. In the control, six of ten dogs showed infarctions verified as histological changes on the seventh post-ischemic day. In the mannitol group only one of ten showed infarction. Each of the difference is statistically significant (P less than 0.03).
在一次动脉瘤手术中，术前给予甘露醇时，有一天，供血动脉意外地被暂时阻断。从那时起，利用犬丘脑梗死模型对甘露醇是否能预防缺血性脑组织梗死进行了研究。20只犬被分成相等的两组，即对照组和甘露醇组。两组均采用暂时夹闭60分钟作为标准。两组之间的唯一区别是在动脉阻断前给予2g/kg的甘露醇。在对照组中，10只犬中有6只在缺血后第7天经组织学检查证实出现梗死。在甘露醇组中，10只犬中只有1只出现梗死。每组之间的差异均具有统计学意义（P小于0.03）。
