Watanabe T, Yoshimoto T, Ogawa A, Sakamoto T, Suzuki J
No Shinkei Geka. 1979 Sep;7(9):859-66.
We have undertaken an electron microscopical investigation of the effects of mannitol on the development of cerebral infarction using an experimental model for thalamic infarction in dogs. 1) It was found that administration of 20% mannitol (2 g/kg) prior to arterial occlusion had significantly suppressive effects upon the formation of cerebral infarction following occlusion. 2) In the control group, only one animal with 30 minutes occlusion showed no pathological changes, but, in the mannitol group, dogs with normal brain tissue were seen even after 120 minutes occlusion. 3) All of the control animals with 60 minutes occlusion showed nerve cell shrinkage, but none of the mannitol treated animals showed such changes. 4) After 180 minutes of arterial occlusion, no notable differences were found between the control and mannitol groups. In one of the mannitol treated animals, cerebral infarction was more severe than in the control group.
我们使用犬丘脑梗死实验模型，对甘露醇对脑梗死发展的影响进行了电子显微镜研究。1）发现在动脉闭塞前给予20%甘露醇（2克/千克）对闭塞后脑梗死的形成具有显著的抑制作用。2）在对照组中，只有一只闭塞30分钟的动物未出现病理变化，但在甘露醇组中，即使闭塞120分钟后仍可见脑组织正常的犬。3）所有闭塞60分钟的对照动物均出现神经细胞萎缩，但甘露醇处理的动物均未出现此类变化。4）动脉闭塞180分钟后，对照组和甘露醇组之间未发现明显差异。在一只甘露醇处理的动物中，脑梗死比对照组更严重。
