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[利用AT III-肝素复合物抗Xa活性的计时评估实现肝素测定的自动化]

[Automatization of heparin determination using chronometric evaluation of anti-Xa activity of the AT III-heparin complex].

作者信息

Sampol J, Rossi J M, Lejay G

出版信息

Ann Biol Clin (Paris). 1984;42(1):21-3.

PMID:6731952
Abstract

The authors describe an adaptation on a semi- automatique coagulometer KC 10 of a manual assay of anti-Xa activity of the Heparin-Antithrombin III Complex close to the technique described by Yin and al. ( Hepaclot - Stago ). The results show a good linearity and a good reproducibility, with a better sensitivity than the manuel method. Freezing has no influence. Significant differences were observed between our assay and the manuel anti-IIa assay. These last results neither depend on the administration route nor on the heparin batches.

摘要

作者描述了一种在半自动凝血仪KC 10上对肝素-抗凝血酶III复合物抗Xa活性的手动检测方法的改编,该方法与Yin等人(Hepaclot - Stago)所描述的技术相近。结果显示出良好的线性和可重复性,并且比手动方法具有更高的灵敏度。冷冻没有影响。在我们的检测方法与手动抗IIa检测方法之间观察到了显著差异。这些最终结果既不取决于给药途径,也不取决于肝素批次。

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