Donham K J, Leininger J R
Am J Vet Res. 1984 May;45(5):926-31.
The pathologic changes in laboratory animals housed in a swine confinement building were studied to predict potential chronic health effects on persons working in these buildings. Rabbits and guinea pigs were maintained for 12 months either in a confined nursery-grower unit (test animals) or in conventional laboratory animal housing (controls). Necropsies and histopathologic examinations were performed on animals that died prematurely or were killed at termination of the study. Blood serum from the animals was examined for antibodies to extracts from swine confinement house dust. The confinement atmosphere was monitored for environmental pollutants. Concentrations of gases and dust in the air of the confinement building were comparable to those found in a typical swine confinement building. Pulmonic lesions seen in the test rabbits and guinea pigs included diffuse interstitial histiocytic pneumonia. Tracheal and nasal turbinate lesions included epithelial hyperplasia and metaplasia, with submucosal infiltration of plasma cells and heterophils. Blood from the test animals contained serum precipitins to dust extract from confinement houses. The presence of precipitins combined with the microscopic appearance of the lungs indicated that an immunologic process, such as hypersensitivity pneumonitis, may be used to explain the basis of the observed lung lesions. The tracheal and turbinate lesions are best explained as a reaction to a chronic low-grade irritation.
研究了饲养在猪舍中的实验动物的病理变化，以预测对在这些猪舍中工作的人员可能产生的慢性健康影响。将兔子和豚鼠在封闭的保育-育肥单元（实验动物）或传统实验动物饲养环境（对照）中饲养12个月。对过早死亡或在研究结束时被处死的动物进行尸检和组织病理学检查。检测动物血清中针对猪舍灰尘提取物的抗体。监测封闭环境中的环境污染物。封闭猪舍空气中的气体和灰尘浓度与典型猪舍中的浓度相当。在实验兔子和豚鼠中观察到的肺部病变包括弥漫性间质性组织细胞性肺炎。气管和鼻甲病变包括上皮增生和化生，伴有浆细胞和嗜异性粒细胞的粘膜下浸润。实验动物的血液中含有针对封闭猪舍灰尘提取物的血清沉淀素。沉淀素的存在与肺部的微观表现表明，免疫过程，如过敏性肺炎，可能是观察到的肺部病变的基础。气管和鼻甲病变最好解释为对慢性低度刺激的反应。
