Flory W, Hebert C D
Am J Vet Res. 1984 May;45(5):955-8.
Extracts of Sesbania drummondii administered to chickens by oral intubation are lethal within several days. Effects are dose-dependent; a dose of 1% of body weight is uniformly lethal in 5 days. Signs of poisoning include weakness, depression (CNS), anorexia, diarrhea, ruffled feathers, cold feet, and rapid loss of body weight. Microscopic examination indicates damage to kidney glomeruli and leakage of protein into the kidney tubules. Packed cell volume and plasma glucose concentrations show no difference between controls and treated chickens; however, creatine kinase is increased and plasma cholinesterase and total plasma protein values are severely depressed in poisoned birds. Neither a specific toxin nor a mechanism of action for toxicity has yet been identified.
通过口服插管给鸡施用的鼓槌田菁提取物在几天内具有致死性。其作用具有剂量依赖性；体重1%的剂量在5天内均具有致死性。中毒症状包括虚弱、抑郁（中枢神经系统）、厌食、腹泻、羽毛蓬松、脚部冰凉以及体重迅速减轻。显微镜检查表明肾小球受损，蛋白质渗漏到肾小管中。红细胞压积和血浆葡萄糖浓度在对照组和处理过的鸡之间没有差异；然而，中毒鸡的肌酸激酶升高，血浆胆碱酯酶和总血浆蛋白值严重降低。尚未确定具体的毒素或毒性作用机制。
