Korsbäck C, Höckerstedt K
Ann Chir Gynaecol. 1982;71(2):112-6.
It has been suspected that vasopressin infusion may cause small bowel necrosis and liver ischaemia. In this study a direct method of measuring the oxygen tension of these organs during intravenous vasopressin infusion was used for the first time. Vasopressin in a dose of 2.75 mU/kg/min was infused during a 45 minute period in ten dogs. Both intestinal and liver pO2 decreased to a hypoxic level. This level was observed within a mean time of 25 minutes in both organs. After discontinuing the vasopressin infusion the oxygen tension was noted to return to normal in 45 minutes. It is concluded that vasopressin causes definite ischaemia of the small bowel and the liver parenchyma, and consequently this vasoactive drug should be used with care. The exact time of onset and duration of intestinal hypoxia could be of great value in planning vasopressin induced hypoxia for radioprotection.
一直有人怀疑输注血管加压素可能会导致小肠坏死和肝脏缺血。在本研究中，首次使用了一种在静脉输注血管加压素期间直接测量这些器官氧张力的方法。在45分钟内，以2.75 mU/kg/分钟的剂量给十只狗输注血管加压素。肠道和肝脏的pO2均降至缺氧水平。两个器官在平均25分钟内观察到该水平。停止输注血管加压素后，氧张力在45分钟内恢复正常。得出的结论是，血管加压素会导致小肠和肝实质出现明确的缺血，因此，这种血管活性药物应谨慎使用。肠道缺氧的确切起始时间和持续时间对于规划血管加压素诱导的缺氧以进行辐射防护可能具有重要价值。
