Trifonova Zh P, Eganian E R, Silaev A B, Katrukha G S
Antibiotiki. 1984 Mar;29(3):170-5.
The chemical and physicochemical characteristics of one of the two inactive components, i.e. the reduced product of alkaline inactivation (PAH-II) of ristomycin. A were studied. The components formed on the antibiotic incubation in mild alkaline media: 0.05 M NaOH, 37 degrees C, 1.5-2 hours. It was shown that the retroaldol cleavage of the C alpha-C beta bond of the phenol serine fragment of the trinuclear dideschlorvancomycinic acid G at the aglycone N-end was one of the causes of ristomycin A rapid inactivation under such conditions.
研究了瑞斯托霉素A两种无活性成分之一的化学和物理化学特性，即碱性失活的还原产物（PAH-II）。这些成分是在抗生素于温和碱性介质（0.05 M NaOH，37℃，1.5 - 2小时）中孵育时形成的。结果表明，在糖苷配基N端，三核二去氯万古霉素酸G的酚丝氨酸片段的Cα - Cβ键发生逆羟醛裂解是瑞斯托霉素A在这种条件下快速失活的原因之一。
