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用于评估皮肤癌风险以及对紫外线B和口服甲氧沙林光化学疗法急性反应的皮肤分型。

Skin typing for assessment of skin cancer risk and acute response to UV-B and oral methoxsalen photochemotherapy.

作者信息

Stern R S, Momtaz K

出版信息

Arch Dermatol. 1984 Jul;120(7):869-73.

PMID:6732259
Abstract

Skin typing is a clinical classification system based on a patient's historical reporting of the acute skin response to sunlight. It is advocated as a means of determining an individual's relative risk of skin tumors and has been used to determine the initial therapeutic dose of UV radiation for UV-B phototherapy or oral methoxsalen photochemotherapy (PUVA) for psoriasis. Among PUVA-treated patients, the relative risk of cutaneous carcinoma was significantly higher among patients with skin types I and II compared with patients with skin type IV (3.2 and 2.3, respectively). Skin type was a better predictor of this risk than eye or hair color. The minimal erythemal dose ( MErD ) and minimal phototoxic dose (MPD) increased with increasing skin type number, but within a given skin type each varied as much as sixfold. Skin type was a good clinical predictor of skin cancer risk, but lacked specificity as a predictor of an individual's MErD or MPD.

摘要

皮肤分型是一种基于患者对阳光急性皮肤反应的历史报告的临床分类系统。它被提倡作为确定个体患皮肤肿瘤相对风险的一种方法,并已用于确定紫外线B光疗或口服甲氧沙林光化学疗法(PUVA)治疗银屑病的初始紫外线辐射治疗剂量。在接受PUVA治疗的患者中,皮肤I型和II型患者患皮肤癌的相对风险显著高于皮肤IV型患者(分别为3.2和2.3)。皮肤类型比眼睛或头发颜色更能预测这种风险。最小红斑剂量(MErD)和最小光毒性剂量(MPD)随着皮肤类型编号的增加而增加,但在给定的皮肤类型内,每种剂量的变化幅度高达六倍。皮肤类型是皮肤癌风险的良好临床预测指标,但作为个体MErD或MPD的预测指标缺乏特异性。

相似文献

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Skin typing for assessment of skin cancer risk and acute response to UV-B and oral methoxsalen photochemotherapy.用于评估皮肤癌风险以及对紫外线B和口服甲氧沙林光化学疗法急性反应的皮肤分型。
Arch Dermatol. 1984 Jul;120(7):869-73.
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Self-reported pigmentary phenotypes and race are significant but incomplete predictors of Fitzpatrick skin phototype in an ethnically diverse population.在种族多样化的人群中,自我报告的色素沉着表型和种族是菲茨帕特里克皮肤光类型的重要但不完整的预测指标。
J Am Acad Dermatol. 2014 Oct;71(4):731-7. doi: 10.1016/j.jaad.2014.05.023. Epub 2014 Jun 11.
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Fitzpatrick skin phototype is an independent predictor of squamous cell carcinoma risk after solid organ transplantation.菲茨帕特里克皮肤光型是实体器官移植后鳞状细胞癌风险的独立预测因子。
J Am Acad Dermatol. 2013 Apr;68(4):585-591. doi: 10.1016/j.jaad.2012.09.030. Epub 2012 Oct 26.
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[Cancer prevention of the skin].
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Clinical pharmacokinetics of methoxsalen and other psoralens.
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