Bech-Thomsen N, Angelo H R, Wulf H C
Department of Dermatology, Copenhagen University Hospital, Rigshopitalet, Denmark.
Arch Dermatol. 1994 Apr;130(4):464-8.
Twenty-eight subjects were phototested to determine their erythemal responses to oral methoxsalen with UV-A and UV-B irradiation. Skin pigmentation was measured by skin reflectance at 550 and 660 nm before irradiation. The smallest UV radiation dose to produce erythema (minimal phototoxic dose and minimal erythema dose, respectively) was determined. The serum concentration of methoxsalen was measured at the time of UV-A irradiation.
There was a positive correlation between skin pigmentation and both 72-hour minimal phototoxic dose and 24-hour minimal erythema dose. No correlation was demonstrated between methoxsalen serum concentration and minimal phototoxic dose. The combination of skin pigmentation and methoxsalen level did not give a better prediction of minimal phototoxic dose than skin pigmentation alone.
Skin pigmentation measurements can be used to predict the minimal phototoxic and erythema doses. Skin pigmentation measurements are easy to perform and should be included in both phototherapy and photochemotherapy to improve the efficiency and reliability of the treatment.
对28名受试者进行光测试，以确定他们口服甲氧沙林后接受紫外线A和紫外线B照射时的红斑反应。在照射前，通过测量550和660纳米处的皮肤反射率来测定皮肤色素沉着。确定产生红斑的最小紫外线辐射剂量（分别为最小光毒性剂量和最小红斑剂量）。在紫外线A照射时测量甲氧沙林的血清浓度。
皮肤色素沉着与72小时最小光毒性剂量和24小时最小红斑剂量之间呈正相关。甲氧沙林血清浓度与最小光毒性剂量之间未显示出相关性。皮肤色素沉着和甲氧沙林水平的组合对最小光毒性剂量的预测效果并不比单独的皮肤色素沉着更好。
皮肤色素沉着测量可用于预测最小光毒性和红斑剂量。皮肤色素沉着测量易于进行，应纳入光疗和光化学疗法中，以提高治疗的效率和可靠性。
