Gould S F, Shannon J M
Arch Gynecol. 1984;234(3):231-4. doi: 10.1007/BF00570760.
Estrogen binding sites in a benign mesothelioma of the uterus was studied by in vitro steroid autoradiography. Unlike normal myometrium, which shows distinct supanuclear localizations of tritiated estradiol, the cellular components of the benign mesothelioma do not appear to have estrogen receptors. Serial sections through the tumor failed to localize sites of estrogen binding. These findings are congruent with an undifferentiated mesothelial organ for the tumor and suggest a lack of response to endogenous sex steroids.
通过体外类固醇放射自显影术研究了子宫良性间皮瘤中的雌激素结合位点。与正常子宫肌层不同，正常子宫肌层显示出氚标记雌二醇的明显核上定位，而良性间皮瘤的细胞成分似乎没有雌激素受体。肿瘤的连续切片未能定位雌激素结合位点。这些发现与肿瘤的未分化间皮器官一致，并提示对内源性性激素缺乏反应。
